APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.

J Cereb Blood Flow Metab
Authors
Keywords
Abstract

Apolipoprotein E (APOE) increases the risk for Alzheimer’s disease (ɛ4 allele) and cerebral amyloid angiopathy (ɛ2 and ɛ4), but its role in small vessel disease (SVD) is debated. Here we studied the effects of APOE on white matter hyperintensity volume (WMHV) in CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), a nonamyloidogenic angiopathy and inherited early-onset form of pure SVD. Four hundred and eighty-eight subjects were recruited through a multicenter consortium. Compared with APOE ɛ3/ɛ3, WMHV was increased in APOE ɛ2 (P = 0.02) but not APOE ɛ4. The results remained significant when controlled for genome-wide genetic background variation. Our findings suggest a modifying influence of APOE ɛ2 on WMHV caused by pure SVD.

Year of Publication
2016
Journal
J Cereb Blood Flow Metab
Volume
36
Issue
1
Pages
199-203
Date Published
2016 Jan
ISSN
1559-7016
URL
DOI
10.1038/jcbfm.2015.85
PubMed ID
25920955
PubMed Central ID
PMC4758562
Links
Grant list
G0900295 / Medical Research Council / United Kingdom
5P50NS051343 / NS / NINDS NIH HHS / United States
K23NS064052 / NS / NINDS NIH HHS / United States
R01NS059727 / NS / NINDS NIH HHS / United States