The tumor virus landscape of AIDS-related lymphomas.

Blood
Authors
Keywords
Abstract

Immunodeficiency dramatically increases susceptibility to cancer as a result of reduced immune surveillance and enhanced opportunities for virus-mediated oncogenesis. Although AIDS-related lymphomas (ARLs) are frequently associated with known oncogenic viruses, many cases contain no known transforming virus. To discover novel transforming viruses, we profiled a set of ARL samples using whole transcriptome sequencing. We determined that Epstein-Barr virus (EBV) was the only virus detected in the tumor samples of this cohort, suggesting that if unidentified pathogens exist in this disease, they are present in

Year of Publication
2015
Journal
Blood
Volume
125
Issue
20
Pages
e14-22
Date Published
2015 May 14
ISSN
1528-0020
URL
DOI
10.1182/blood-2014-11-599951
PubMed ID
25827832
PubMed Central ID
PMC4432014
Links
Grant list
1RC2CA148317 / CA / NCI NIH HHS / United States
RC2 CA148317 / CA / NCI NIH HHS / United States
U01CA121947 / CA / NCI NIH HHS / United States
UM1 CA181255 / CA / NCI NIH HHS / United States
1UM1CA181255 / CA / NCI NIH HHS / United States
UM1 CA121947 / CA / NCI NIH HHS / United States
U01 CA121947 / CA / NCI NIH HHS / United States