The tumor virus landscape of AIDS-related lymphomas.
Blood
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Abstract | Immunodeficiency dramatically increases susceptibility to cancer as a result of reduced immune surveillance and enhanced opportunities for virus-mediated oncogenesis. Although AIDS-related lymphomas (ARLs) are frequently associated with known oncogenic viruses, many cases contain no known transforming virus. To discover novel transforming viruses, we profiled a set of ARL samples using whole transcriptome sequencing. We determined that Epstein-Barr virus (EBV) was the only virus detected in the tumor samples of this cohort, suggesting that if unidentified pathogens exist in this disease, they are present in |
Year of Publication | 2015
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Journal | Blood
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Volume | 125
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Issue | 20
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Pages | e14-22
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Date Published | 2015 May 14
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ISSN | 1528-0020
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URL | |
DOI | 10.1182/blood-2014-11-599951
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PubMed ID | 25827832
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PubMed Central ID | PMC4432014
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Grant list | 1RC2CA148317 / CA / NCI NIH HHS / United States
RC2 CA148317 / CA / NCI NIH HHS / United States
U01CA121947 / CA / NCI NIH HHS / United States
UM1 CA181255 / CA / NCI NIH HHS / United States
1UM1CA181255 / CA / NCI NIH HHS / United States
UM1 CA121947 / CA / NCI NIH HHS / United States
U01 CA121947 / CA / NCI NIH HHS / United States
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