Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.

Diabetes
Authors
Keywords
Abstract

Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10(-107)) and stratified analyses (all P

Year of Publication
2015
Journal
Diabetes
Volume
64
Issue
5
Pages
1841-52
Date Published
2015 May
ISSN
1939-327X
URL
DOI
10.2337/db14-0988
PubMed ID
25712996
PubMed Central ID
PMC4407863
Links
Grant list
RC2 MH089951 / MH / NIMH NIH HHS / United States
R01 MH063706 / MH / NIMH NIH HHS / United States
British Heart Foundation / United Kingdom
R01 AA007535 / AA / NIAAA NIH HHS / United States
N01-RC-45035 / RC / CCR NIH HHS / United States
090532 / Wellcome Trust / United Kingdom
R01 AA014041 / AA / NIAAA NIH HHS / United States
R01 MH081802 / MH / NIMH NIH HHS / United States
R01 HL087679 / HL / NHLBI NIH HHS / United States
RC2 MH089995 / MH / NIMH NIH HHS / United States
AA-10248 / AA / NIAAA NIH HHS / United States
079895 / Wellcome Trust / United Kingdom
MH-081802 / MH / NIMH NIH HHS / United States
AA-07535 / AA / NIAAA NIH HHS / United States
U01-DK-062418 / DK / NIDDK NIH HHS / United States
1RC2-MH-089951-01 / MH / NIMH NIH HHS / United States
G0500539 / Medical Research Council / United Kingdom
R01-D0042157-01A / PHS HHS / United States
1RC2-MH-089995-01 / MH / NIMH NIH HHS / United States
MR/N01104X/1 / Medical Research Council / United Kingdom
5R01MH63706-02 / MH / NIMH NIH HHS / United States
U01 DK062418 / DK / NIDDK NIH HHS / United States
U24 MH068457 / MH / NIMH NIH HHS / United States
G0902313 / Medical Research Council / United Kingdom
N01RC37004 / RC / CCR NIH HHS / United States
U24-MH-068457-06 / MH / NIMH NIH HHS / United States
068545/Z/02 / Wellcome Trust / United Kingdom
5R01HL087679-02 / HL / NHLBI NIH HHS / United States
098381 / Wellcome Trust / United Kingdom
RL1 MH083268 / MH / NIMH NIH HHS / United States
N01 CN045165 / CN / NCI NIH HHS / United States
RC2MH089951 / MH / NIMH NIH HHS / United States
76113/B/04/Z / Wellcome Trust / United Kingdom
G0000934 / Medical Research Council / United Kingdom
MR/L01629X/1 / Medical Research Council / United Kingdom
AA-014041 / AA / NIAAA NIH HHS / United States
G0600705 / Medical Research Council / United Kingdom