Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.

PLoS Genet
Authors
Keywords
Abstract

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry. We found exome-wide significant (P

Year of Publication
2015
Journal
PLoS Genet
Volume
11
Issue
1
Pages
e1004876
Date Published
2015 Jan
ISSN
1553-7404
URL
DOI
10.1371/journal.pgen.1004876
PubMed ID
25625282
PubMed Central ID
PMC4307976
Links
Grant list
R01 DK093757 / DK / NIDDK NIH HHS / United States
R01 DK078616 / DK / NIDDK NIH HHS / United States
UL1 TR000430 / TR / NCATS NIH HHS / United States
098017 / Wellcome Trust / United Kingdom
DK085524 / DK / NIDDK NIH HHS / United States
R01 DK098032 / DK / NIDDK NIH HHS / United States
R01 DK072193 / DK / NIDDK NIH HHS / United States
WT098381 / Wellcome Trust / United Kingdom
095010/Z/10/Z / Wellcome Trust / United Kingdom
K24 DK080140 / DK / NIDDK NIH HHS / United States
090532 / Wellcome Trust / United Kingdom
DK085584 / DK / NIDDK NIH HHS / United States
DK085545 / DK / NIDDK NIH HHS / United States
U01 DK078616 / DK / NIDDK NIH HHS / United States
DK085526 / DK / NIDDK NIH HHS / United States
U01 DK062370 / DK / NIDDK NIH HHS / United States
DK085501 / DK / NIDDK NIH HHS / United States
WT090532 / Wellcome Trust / United Kingdom
P30 DK020572 / DK / NIDDK NIH HHS / United States
WT098017 / Wellcome Trust / United Kingdom
095101 / Wellcome Trust / United Kingdom
098381 / Wellcome Trust / United Kingdom
086596/Z/08/Z / Wellcome Trust / United Kingdom
WT064890 / Wellcome Trust / United Kingdom
G0601261 / Medical Research Council / United Kingdom
P30 DK020595 / DK / NIDDK NIH HHS / United States