Synaptic, transcriptional and chromatin genes disrupted in autism.

Nature
Authors
Keywords
Abstract

The genetic architecture of autism spectrum disorder involves the interplay of common and rare variants and their impact on hundreds of genes. Using exome sequencing, here we show that analysis of rare coding variation in 3,871 autism cases and 9,937 ancestry-matched or parental controls implicates 22 autosomal genes at a false discovery rate (FDR)

Year of Publication
2014
Journal
Nature
Volume
515
Issue
7526
Pages
209-15
Date Published
2014 Nov 13
ISSN
1476-4687
URL
DOI
10.1038/nature13772
PubMed ID
25363760
PubMed Central ID
PMC4402723
Links
Grant list
MH077139 / MH / NIMH NIH HHS / United States
R01 MH100229 / MH / NIMH NIH HHS / United States
R01 MH083565 / MH / NIMH NIH HHS / United States
UL1 TR000445 / TR / NCATS NIH HHS / United States
RC2MH089952 / MH / NIMH NIH HHS / United States
R01 MH089208 / MH / NIMH NIH HHS / United States
R01 MH095034 / MH / NIMH NIH HHS / United States
UL1TR000445 / TR / NCATS NIH HHS / United States
R37 MH057881 / MH / NIMH NIH HHS / United States
R01 MH097849 / MH / NIMH NIH HHS / United States
G0500870 / Medical Research Council / United Kingdom
U54 HG003067 / HG / NHGRI NIH HHS / United States
U01 MH100229 / MH / NIMH NIH HHS / United States
091986 / Wellcome Trust / United Kingdom
U01MH100233 / MH / NIMH NIH HHS / United States
R01 MH077139 / MH / NIMH NIH HHS / United States
MH095034 / MH / NIMH NIH HHS / United States
R01 MH061009 / MH / NIMH NIH HHS / United States
RC2 MH089952 / MH / NIMH NIH HHS / United States
P30 HD015052 / HD / NICHD NIH HHS / United States
U01 MH100209 / MH / NIMH NIH HHS / United States
T32 HG002295 / HG / NHGRI NIH HHS / United States
U01 MH100239 / MH / NIMH NIH HHS / United States
WT098051 / Wellcome Trust / United Kingdom
R01 NS073601 / NS / NINDS NIH HHS / United States
U01MH100239 / MH / NIMH NIH HHS / United States
R01MH083565 / MH / NIMH NIH HHS / United States
P50 HD055751 / HD / NICHD NIH HHS / United States
R01MH089208 / MH / NIMH NIH HHS / United States
Howard Hughes Medical Institute / United States
R01 MH094400 / MH / NIMH NIH HHS / United States
WT091310 / Wellcome Trust / United Kingdom
UL1 RR024975 / RR / NCRR NIH HHS / United States
U01MH100209 / MH / NIMH NIH HHS / United States
5UL1 RR024975 / RR / NCRR NIH HHS / United States
U01MH100229 / MH / NIMH NIH HHS / United States
MR/L010305/1 / Medical Research Council / United Kingdom
R01 MH095797 / MH / NIMH NIH HHS / United States
U01 MH100233 / MH / NIMH NIH HHS / United States
P30 HD15052 / HD / NICHD NIH HHS / United States
MH089482 / MH / NIMH NIH HHS / United States
R01 MH089482 / MH / NIMH NIH HHS / United States