Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.
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Abstract | Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease. |
Year of Publication | 2015
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Journal | Mol Psychiatry
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Volume | 20
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Issue | 10
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Pages | 1232-9
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Date Published | 2015 Oct
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ISSN | 1476-5578
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URL | |
DOI | 10.1038/mp.2014.133
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PubMed ID | 25469926
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PubMed Central ID | PMC4430294
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Grant list | N01HC55020 / HL / NHLBI NIH HHS / United States
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