Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.

Schizophr Res
Authors
Keywords
Abstract

The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs. 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs. 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.

Year of Publication
2014
Journal
Schizophr Res
Volume
159
Issue
2-3
Pages
539-42
Date Published
2014 Nov
ISSN
1573-2509
URL
DOI
10.1016/j.schres.2014.09.023
PubMed ID
25311778
PubMed Central ID
PMC4476307
Links
Grant list
R34 MH100776 / MH / NIMH NIH HHS / United States
R34MH100776 / MH / NIMH NIH HHS / United States