Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Nature
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Abstract | Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P |
Year of Publication | 2014
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Journal | Nature
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Volume | 514
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Issue | 7520
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Pages | 92-7
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Date Published | 2014 Oct 02
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ISSN | 1476-4687
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URL | |
DOI | 10.1038/nature13545
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PubMed ID | 25231870
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PubMed Central ID | PMC4185210
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Grant list | R01 NS017950 / NS / NINDS NIH HHS / United States
MC_UU_12013/3 / Medical Research Council / United Kingdom
G1000143 / Medical Research Council / United Kingdom
MR/J012165/1 / Medical Research Council / United Kingdom
R01 AG041517 / AG / NIA NIH HHS / United States
UL1 TR001108 / TR / NCATS NIH HHS / United States
102215 / Wellcome Trust / United Kingdom
MC_UU_12015/1 / Medical Research Council / United Kingdom
MC_U106179471 / Medical Research Council / United Kingdom
MC_UU_12015/2 / Medical Research Council / United Kingdom
MC_PC_15018 / Medical Research Council / United Kingdom
MC_U106179472 / Medical Research Council / United Kingdom
P50 CA116201 / CA / NCI NIH HHS / United States
G0401527 / Medical Research Council / United Kingdom
MC_UU_12013/1 / Medical Research Council / United Kingdom
G0701863 / Medical Research Council / United Kingdom
098381 / Wellcome Trust / United Kingdom
10118 / Cancer Research UK / United Kingdom
G9815508 / Medical Research Council / United Kingdom
10124 / Cancer Research UK / United Kingdom
U01 AG049505 / AG / NIA NIH HHS / United States
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