Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

Nature
Authors
Keywords
Abstract

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P 

Year of Publication
2014
Journal
Nature
Volume
514
Issue
7520
Pages
92-7
Date Published
2014 Oct 02
ISSN
1476-4687
URL
DOI
10.1038/nature13545
PubMed ID
25231870
PubMed Central ID
PMC4185210
Links
Grant list
R01 NS017950 / NS / NINDS NIH HHS / United States
MC_UU_12013/3 / Medical Research Council / United Kingdom
G1000143 / Medical Research Council / United Kingdom
MR/J012165/1 / Medical Research Council / United Kingdom
R01 AG041517 / AG / NIA NIH HHS / United States
UL1 TR001108 / TR / NCATS NIH HHS / United States
102215 / Wellcome Trust / United Kingdom
MC_UU_12015/1 / Medical Research Council / United Kingdom
MC_U106179471 / Medical Research Council / United Kingdom
MC_UU_12015/2 / Medical Research Council / United Kingdom
MC_PC_15018 / Medical Research Council / United Kingdom
MC_U106179472 / Medical Research Council / United Kingdom
P50 CA116201 / CA / NCI NIH HHS / United States
G0401527 / Medical Research Council / United Kingdom
MC_UU_12013/1 / Medical Research Council / United Kingdom
G0701863 / Medical Research Council / United Kingdom
098381 / Wellcome Trust / United Kingdom
10118 / Cancer Research UK / United Kingdom
G9815508 / Medical Research Council / United Kingdom
10124 / Cancer Research UK / United Kingdom
U01 AG049505 / AG / NIA NIH HHS / United States