The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.

Bioinformatics
Authors
Keywords
Abstract

MOTIVATION: The naked mole rat (Heterocephalus glaber) is an exceptionally long-lived and cancer-resistant rodent native to East Africa. Although its genome was previously sequenced, here we report a new assembly sequenced by us with substantially higher N50 values for scaffolds and contigs.

RESULTS: We analyzed the annotation of this new improved assembly and identified candidate genomic adaptations which may have contributed to the evolution of the naked mole rat's extraordinary traits, including in regions of p53, and the hyaluronan receptors CD44 and HMMR (RHAMM). Furthermore, we developed a freely available web portal, the Naked Mole Rat Genome Resource (http://www.naked-mole-rat.org), featuring the data and results of our analysis, to assist researchers interested in the genome and genes of the naked mole rat, and also to facilitate further studies on this fascinating species.

Year of Publication
2014
Journal
Bioinformatics
Volume
30
Issue
24
Pages
3558-60
Date Published
2014 Dec 15
ISSN
1367-4811
URL
DOI
10.1093/bioinformatics/btu579
PubMed ID
25172923
PubMed Central ID
PMC4253829
Links
Grant list
P01 AG047200 / AG / NIA NIH HHS / United States
R01 AG027237 / AG / NIA NIH HHS / United States
094386MA / Wellcome Trust / United Kingdom