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The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma.
|Publication Type||Journal Article|
|Authors||Davis, CF, Ricketts CJ, Wang M., Yang L., Cherniack AD, Shen H., Buhay C., Kang H., Kim SC, Fahey CC, Hacker KE, Bhanot G., Gordenin DA, Chu A., Gunaratne PH, Biehl M., Seth S., Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P., Reuter V., Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, The Cancer Genome Atlas Research Network, Chin L., Meyerson M., Kucherlapati R., Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M., Shuch B., Muzny D., Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ, and The Cancer Genome Atlas Research Network|
|Abstract||We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.|
|Year of Publication||2014|
|Date Published (YYYY/MM/DD)||2014/08/20|