Scientific Publications

Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.

Publication TypeJournal Article
AuthorsFox, IJ, Daley GQ, Goldman SA, Huard J., Kamp TJ, and Trucco M.
AbstractPluripotent stem cells (PSCs) directed to various cell fates holds promise as source material for treating numerous disorders. The availability of precisely differentiated PSC-derived cells will dramatically affect blood component and hematopoietic stem cell therapies and should facilitate treatment of diabetes, some forms of liver disease and neurologic disorders, retinal diseases, and possibly heart disease. Although an unlimited supply of specific cell types is needed, other barriers must be overcome. This review of the state of cell therapies highlights important challenges. Successful cell transplantation will require optimizing the best cell type and site for engraftment, overcoming limitations to cell migration and tissue integration, and occasionally needing to control immunologic reactivity, as well as a number of other challenges. Collaboration among scientists, clinicians, and industry is critical for generating new stem cell-based therapies.
Year of Publication2014
JournalScience (New York, N.Y.)
Volume345
Issue6199
Pages1247391
Date Published (YYYY/MM/DD)2014/08/22
ISSN Number0036-8075
DOI10.1126/science.1247391
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/25146295?dopt=Abstract