Genome-wide association analyses identify variants in developmental genes associated with hypospadias.

Nat Genet
Authors
Keywords
Abstract

Hypospadias is a common congenital condition in boys in which the urethra opens on the underside of the penis. We performed a genome-wide association study on 1,006 surgery-confirmed hypospadias cases and 5,486 controls from Denmark. After replication genotyping of an additional 1,972 cases and 1,812 controls from Denmark, the Netherlands and Sweden, 18 genomic regions showed independent association with P

Year of Publication
2014
Journal
Nat Genet
Volume
46
Issue
9
Pages
957-63
Date Published
2014 Sep
ISSN
1546-1718
URL
DOI
10.1038/ng.3063
PubMed ID
25108383
Links
Grant list
5K12DK083021 / DK / NIDDK NIH HHS / United States