Scientific Publications

Fungi on the Skin: Dermatophytes and Malassezia.

Publication TypeJournal Article
AuthorsWhite, TC, Findley K., Dawson TL Jr, Scheynius A., Boekhout T., Cuomo CA, Xu J., and Saunders CW
AbstractSeveral human skin diseases and disorders are associated with two groups of fungi, the dermatophytes and Malassezia. Although these skin-related problems are not generally life threatening, they are among the most common diseases and disorders of mankind. These fungi are phylogenetically divergent, with the dermatophytes within the Ascomycota and Malassezia within Basidiomycota. Genome analysis indicates that the adaptations to the skin environment are different in these two groups of fungi. Malassezia are dependent on host lipids and secrete lipases and phospholipases that likely release host fatty acids. The dermatophytes encode multiple enzymes with potential roles in modulating host interactions: polyketide synthases, nonribosomal peptide synthetases, LysM, proteases, kinases, and pseudokinases. These two fungal groups have maximized their interactions with the host using two very different mechanisms.
Year of Publication2014
JournalCold Spring Harbor perspectives in medicine
Volume4
Issue8
Date Published (YYYY/MM/DD)2014/08/01
DOI10.1101/cshperspect.a019802
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/25085959?dopt=Abstract