Scientific Publications

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.

Publication TypeJournal Article
AuthorsMcAllister, SS, and Weinberg R. A.
AbstractRecent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
Year of Publication2014
JournalNature cell biology
Volume16
Issue8
Pages717-27
Date Published (YYYY/MM/DD)2014/08/01
ISSN Number1465-7392
DOI10.1038/ncb3015
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/25082194?dopt=Abstract