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The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.
|Publication Type||Journal Article|
|Authors||McAllister, SS, and Weinberg R. A.|
|Abstract||Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.|
|Year of Publication||2014|
|Journal||Nature cell biology|
|Date Published (YYYY/MM/DD)||2014/08/01|