Scientific Publications

Genome-scale neurogenetics: methodology and meaning.

Publication TypeJournal Article
AuthorsMcCarroll, SA, Feng G., and Hyman SE
AbstractGenetic analysis is currently offering glimpses into molecular mechanisms underlying such neuropsychiatric disorders as schizophrenia, bipolar disorder and autism. After years of frustration, success in identifying disease-associated DNA sequence variation has followed from new genomic technologies, new genome data resources, and global collaborations that could achieve the scale necessary to find the genes underlying highly polygenic disorders. Here we describe early results from genome-scale studies of large numbers of subjects and the emerging significance of these results for neurobiology.
Year of Publication2014
JournalNature neuroscience
Volume17
Issue6
Pages756-63
Date Published (YYYY/MM/DD)2014/06/01
ISSN Number1097-6256
DOI10.1038/nn.3716
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24866041?dopt=Abstract