Scientific Publications

Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.

Publication TypeJournal Article
AuthorsPearson-Fuhrhop, KM, Dunn EC, Mortero S., Devan WJ, Falcone GJ, Lee P., Holmes AJ, Hollinshead MO, Roffman JL, Smoller JW, Rosand J., and Cramer SC
AbstractDepression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the pathophysiology of depression, evidence linking dopamine-related genes to depression has been mixed. The current study sought to address this knowledge-gap by examining whether the combined effect of dopamine polymorphisms was associated with depressive symptomatology in both healthy individuals and individuals with depression.
Year of Publication2014
JournalPloS one
Volume9
Issue5
Pagese93772
Date Published (YYYY/MM/DD)2014/01/01
DOI10.1371/journal.pone.0093772
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24834916?dopt=Abstract