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Gut Microbiota and the Paradox of Cancer Immunotherapy.
|Publication Type||Journal Article|
|Authors||Poutahidis, T., Kleinewietfeld M., and Erdman SE|
|Abstract||It is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.|
|Year of Publication||2014|
|Journal||Frontiers in immunology|
|Date Published (YYYY/MM/DD)||2014/01/01|