Scientific Publications

Gut Microbiota and the Paradox of Cancer Immunotherapy.

Publication TypeJournal Article
AuthorsPoutahidis, T., Kleinewietfeld M., and Erdman SE
AbstractIt is recently shown that beneficial environmental microbes stimulate integrated immune and neuroendocrine factors throughout the body, consequently modulating regulatory T-lymphocyte phenotypes, maintaining systemic immune balance, and determining the fate of preneoplastic lesions toward regression while sustaining whole body good health. Stimulated by a gut microbiota-centric systemic homeostasis hypothesis, we set out to explore the influence of the gut microbiome to explain the paradoxical roles of regulatory T-lymphocytes in cancer development and growth. This paradigm shift places cancer prevention and treatment into a new broader context of holobiont engineering to cultivate a tumor-suppressive macroenvironment.
Year of Publication2014
JournalFrontiers in immunology
Volume5
Pages157
Date Published (YYYY/MM/DD)2014/01/01
DOI10.3389/fimmu.2014.00157
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24778636?dopt=Abstract