Scientific Publications

Heterogeneity in immune responses: from populations to single cells.

Publication TypeJournal Article
AuthorsSatija, R., and Shalek AK
AbstractThe mammalian immune system is tasked with protecting the host against a broad range of threats. Understanding how immune populations leverage cellular diversity to achieve this breadth and flexibility, particularly during dynamic processes such as differentiation and antigenic response, is a core challenge that is well suited for single cell analysis. Recent years have witnessed transformative and intersecting advances in nanofabrication and genomics that enable deep profiling of individual cells, affording exciting opportunities to study heterogeneity in the immune response at an unprecedented scope. In light of these advances, here we review recent work exploring how immune populations generate and leverage cellular heterogeneity at multiple molecular and phenotypic levels. Additionally, we highlight opportunities for single cell technologies to shed light on the causes and consequences of heterogeneity in the immune system.
Year of Publication2014
JournalTrends in immunology
Date Published (YYYY/MM/DD)2014/04/16
ISSN Number1471-4906
DOI10.1016/j.it.2014.03.004
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24746883?dopt=Abstract