Regulatory T cells in autoimmune neuroinflammation.

Immunol Rev
Authors
Keywords
Abstract

Regulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4(+) T-helper (Th) cell lineage. These specific subtypes can be discriminated according to phenotype and function. Forkhead box protein 3 (FoxP3)-expressing natural Treg cells (Tregs) and IL-10-producing, T-regulatory type 1 cells (Tr1) are the best-studied types of CD4(+) regulatory T cells in humans and experimental animal models. It was shown that they play a crucial role during autoimmune neuroinflammation. Both cells types seem to be particularly important for multiple sclerosis (MS). Here, we discuss the role of CD4(+) regulatory T cells in autoimmune neuroinflammation with an emphasis on Tregs and Tr1 cells in MS.

Year of Publication
2014
Journal
Immunol Rev
Volume
259
Issue
1
Pages
231-44
Date Published
2014 May
ISSN
1600-065X
URL
DOI
10.1111/imr.12169
PubMed ID
24712469
PubMed Central ID
PMC3990868
Links
Grant list
U19 AI070352 / AI / NIAID NIH HHS / United States
R01 AI091568 / AI / NIAID NIH HHS / United States
R37 NS024247 / NS / NINDS NIH HHS / United States
P01 AI039671 / AI / NIAID NIH HHS / United States
P01 AI045757 / AI / NIAID NIH HHS / United States
U01 AI102011 / AI / NIAID NIH HHS / United States
U19 AI046130 / AI / NIAID NIH HHS / United States