Regulatory T cells in autoimmune neuroinflammation.
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Abstract | Regulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4(+) T-helper (Th) cell lineage. These specific subtypes can be discriminated according to phenotype and function. Forkhead box protein 3 (FoxP3)-expressing natural Treg cells (Tregs) and IL-10-producing, T-regulatory type 1 cells (Tr1) are the best-studied types of CD4(+) regulatory T cells in humans and experimental animal models. It was shown that they play a crucial role during autoimmune neuroinflammation. Both cells types seem to be particularly important for multiple sclerosis (MS). Here, we discuss the role of CD4(+) regulatory T cells in autoimmune neuroinflammation with an emphasis on Tregs and Tr1 cells in MS. |
Year of Publication | 2014
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Journal | Immunol Rev
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Volume | 259
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Issue | 1
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Pages | 231-44
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Date Published | 2014 May
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ISSN | 1600-065X
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URL | |
DOI | 10.1111/imr.12169
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PubMed ID | 24712469
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PubMed Central ID | PMC3990868
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Grant list | U19 AI070352 / AI / NIAID NIH HHS / United States
R01 AI091568 / AI / NIAID NIH HHS / United States
R37 NS024247 / NS / NINDS NIH HHS / United States
P01 AI039671 / AI / NIAID NIH HHS / United States
P01 AI045757 / AI / NIAID NIH HHS / United States
U01 AI102011 / AI / NIAID NIH HHS / United States
U19 AI046130 / AI / NIAID NIH HHS / United States
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