Scientific Publications

Regulatory T cells in autoimmune neuroinflammation.

Publication TypeJournal Article
AuthorsKleinewietfeld, M., and Hafler DA
AbstractRegulatory T cells are the central element for the maintenance of peripheral tolerance. Several subtypes of regulatory T (Treg) cells have been described, and most of them belong to the CD4(+) T-helper (Th) cell lineage. These specific subtypes can be discriminated according to phenotype and function. Forkhead box protein 3 (FoxP3)-expressing natural Treg cells (Tregs) and IL-10-producing, T-regulatory type 1 cells (Tr1) are the best-studied types of CD4(+) regulatory T cells in humans and experimental animal models. It was shown that they play a crucial role during autoimmune neuroinflammation. Both cells types seem to be particularly important for multiple sclerosis (MS). Here, we discuss the role of CD4(+) regulatory T cells in autoimmune neuroinflammation with an emphasis on Tregs and Tr1 cells in MS.
Year of Publication2014
JournalImmunological reviews
Volume259
Issue1
Pages231-44
Date Published (YYYY/MM/DD)2014/05/01
ISSN Number0105-2896
DOI10.1111/imr.12169
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24712469?dopt=Abstract