Scientific Publications

Regulation of mTORC1 by amino acids.

Publication TypeJournal Article
AuthorsBar-Peled, L., and Sabatini DM
AbstractThe mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutrients, such as amino acids, which drive mTORC1 to the lysosomal surface, its site of activation. How amino acid levels are communicated to mTORC1 is only recently coming to light by the discovery of a lysosome-based signaling system composed of Rags (Ras-related GTPases) and Ragulator v-ATPase, GATOR (GAP activity towards Rags), and folliculin (FLCN) complexes. Increased understanding of this pathway will not only provide insight into growth control but also into the human pathologies triggered by its deregulation.
Year of Publication2014
JournalTrends in cell biology
Date Published (YYYY/MM/DD)2014/03/31
ISSN Number0962-8924
DOI10.1016/j.tcb.2014.03.003
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24698685?dopt=Abstract