Scientific Publications

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.

Publication TypeJournal Article
AuthorsMihaylova, MM, Sabatini DM, and Yilmaz OH
AbstractOrganismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alters tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth.
Year of Publication2014
JournalCell stem cell
Volume14
Issue3
Pages292-305
Date Published (YYYY/MM/DD)2014/03/06
ISSN Number1934-5909
DOI10.1016/j.stem.2014.02.008
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24607404?dopt=Abstract