Scientific Publications

Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.

Publication TypeJournal Article
AuthorsZhao, T., Li Y., Liu B., Halaweish I., Mazitschek R., and Alam HB
AbstractPhagocytes, especially monocytes, macrophages, and dendritic cells, play a pivotal role in the innate and adaptive immune responses during sepsis. We have shown that inhibition of histone deacetylase 6 improves survival and increases bacterial clearance in a mouse model of cecal ligation and puncture (CLP). The aim of this study was to determine whether this effect was associated with changes in the number and composition of different blood cell types in the circulation.
Year of Publication2014
JournalThe Journal of surgical research
Date Published (YYYY/MM/DD)2014/02/04
ISSN Number0022-4804
DOI10.1016/j.jss.2014.01.056
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24613069?dopt=Abstract