Scientific Publications

Recent discoveries and applications involving small-molecule microarrays.

Publication TypeJournal Article
AuthorsHong, JA, Neel DV, Wassaf D., Caballero F., and Koehler AN
AbstractHigh-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications.
Year of Publication2014
JournalCurrent opinion in chemical biology
Volume18C
Pages21-28
Date Published (YYYY/MM/DD)2014/02/01
ISSN Number1367-5931
DOI10.1016/j.cbpa.2013.09.020
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24534749?dopt=Abstract