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Recent discoveries and applications involving small-molecule microarrays.
|Publication Type||Journal Article|
|Authors||Hong, JA, Neel DV, Wassaf D., Caballero F., and Koehler AN|
|Abstract||High-throughput and unbiased binding assays have proven useful in probe discovery for a myriad of biomolecules, including targets of unknown structure or function and historically challenging target classes. Over the past decade, a number of novel formats for executing large-scale binding assays have been developed and used successfully in probe discovery campaigns. Here we review the use of one such format, the small-molecule microarray (SMM), as a tool for discovering protein-small molecule interactions. This review will briefly highlight selected recent probe discoveries using SMMs as well as novel uses of SMMs in profiling applications.|
|Year of Publication||2014|
|Journal||Current opinion in chemical biology|
|Date Published (YYYY/MM/DD)||2014/02/01|