Scientific Publications

The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated with Panic Disorder and Amygdala Structure and Function.

Publication TypeJournal Article
AuthorsSmoller, JW, Gallagher PJ, Duncan LE, McGrath LM, Haddad SA, Holmes AJ, Wolf AB, Hilker S., Block SR, Weill S., Young S., Choi EY, Rosenbaum JF, Biederman J., Faraone SV, Roffman JL, Manfro GG, Blaya C., Hirshfeld-Becker DR, Stein MB, Van Ameringen M., Tolin DF, Otto MW, Pollack MH, Simon NM, Buckner RL, Ongür D., and Cohen BM
AbstractIndividuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide-mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function.
Year of Publication2014
JournalBiological psychiatry
Date Published (YYYY/MM/DD)2014/01/18
ISSN Number0006-3223
DOI10.1016/j.biopsych.2013.12.018
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24529281?dopt=Abstract