Scientific Publications

Epigenome-wide association studies without the need for cell-type composition.

Publication TypeJournal Article
AuthorsZou, J., Lippert C., Heckerman D., Aryee M., and Listgarten J.
AbstractIn epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition-information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.
Year of Publication2014
JournalNature methods
Date Published (YYYY/MM/DD)2014/01/26
ISSN Number1548-7091
DOI10.1038/nmeth.2815
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24464286?dopt=Abstract