Epigenome-wide association studies without the need for cell-type composition.

Nat Methods
Authors
Keywords
Abstract

In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition--information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach. Corresponding software is available from http://www.microsoft.com/science/.

Year of Publication
2014
Journal
Nat Methods
Volume
11
Issue
3
Pages
309-11
Date Published
2014 Mar
ISSN
1548-7105
URL
DOI
10.1038/nmeth.2815
PubMed ID
24464286
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