Scientific Publications

Multilocus Genetic Risk Score Associates With Ischemic Stroke in Case-Control and Prospective Cohort Studies.

Publication TypeJournal Article
AuthorsMalik, R., Bevan S., Nalls MA, Holliday EG, Devan WJ, Cheng YC, Ibrahim-Verbaas CA, Verhaaren BF, Bis JC, Joon AY, Destefano AL, Fornage M., Psaty BM, Ikram MA, Launer LJ, van Duijn CM, Sharma P., Mitchell BD, Rosand J., Meschia JF, Levi C., Rothwell PM, Sudlow C., Markus HS, Seshadri S., Dichgans M., and Wellcome Trust Case Control Consortium 2
AbstractGenome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts.
Year of Publication2014
JournalStroke; a journal of cerebral circulation
Date Published (YYYY/MM/DD)2014/01/16
ISSN Number0039-2499
DOI10.1161/STROKEAHA.113.002938
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24436234?dopt=Abstract