Scientific Publications

Comorbidity of Severe Psychotic Disorders With Measures of Substance Use.

Publication TypeJournal Article
AuthorsHartz, SM, Pato CN, Medeiros H., Cavazos-Rehg P., Sobell JL, Knowles JA, Bierut LJ, Pato MT, for the Genomic Psychiatry Cohort Consortium, Abbott C., Azevedo MH, Belliveau R., Bevilacqua E., Bromet EJ, Buckley PF, Dewan MJ, Escamilla MA, Fanous AH, Fochtmann LJ, Kinkead R., Kotov R., Lehrer DS, Macciardi F., Malaspina D., Marder SR, McCarroll SA, Moran J., Morley CP, Nicolini H., Perkins DO, Potkin SG, Purcell SM, Rakofsky JJ, Rapaport MH, Scolnick EM, Sklar B., Sklar P., Smoller JW, Sullivan PF, and Vivar A.
AbstractIMPORTANCE Although early mortality in severe psychiatric illness is linked to smoking and alcohol, to our knowledge, no studies have comprehensively characterized substance use behavior in severe psychotic illness. In particular, recent assessments of substance use in individuals with mental illness are based on population surveys that do not include individuals with severe psychotic illness. OBJECTIVE To compare substance use in individuals with severe psychotic illness with substance use in the general population. DESIGN, SETTING, AND PARTICIPANTS We assessed comorbidity between substance use and severe psychotic disorders in the Genomic Psychiatry Cohort. The Genomic Psychiatry Cohort is a clinically assessed, multiethnic sample consisting of 9142 individuals with the diagnosis of schizophrenia, bipolar disorder with psychotic features, or schizoaffective disorder, and 10 195 population control individuals. MAIN OUTCOMES AND MEASURES Smoking (smoked >100 cigarettes in a lifetime), heavy alcohol use (>4 drinks/day), heavy marijuana use (>21 times of marijuana use/year), and recreational drug use. RESULTS Relative to the general population, individuals with severe psychotic disorders have increased risks for smoking (odds ratio, 4.6; 95% CI, 4.3-4.9), heavy alcohol use (odds ratio, 4.0; 95% CI, 3.6-4.4), heavy marijuana use (odds ratio, 3.5; 95% CI, 3.2-3.7), and recreational drug use (odds ratio, 4.6; 95% CI, 4.3-5.0). All races/ethnicities (African American, Asian, European American, and Hispanic) and both sexes have greatly elevated risks for smoking and alcohol, marijuana, and drug use. Of specific concern, recent public health efforts that have successfully decreased smoking among individuals younger than age 30 years appear to have been ineffective among individuals with severe psychotic illness (interaction effect between age and severe mental illness on smoking initiation, P = 4.5 × 105). CONCLUSIONS AND RELEVANCE In the largest assessment of substance use among individuals with severe psychotic illness to date, we found the odds of smoking and alcohol and other substance use to be dramatically higher than recent estimates of substance use in mild mental illness.
Year of Publication2014
JournalJAMA psychiatry
Date Published (YYYY/MM/DD)2014/01/01
ISSN Number2168-622X