Adult neural stem cells in distinct microdomains generate previously unknown interneuron types.

Nat Neurosci
Authors
Keywords
Abstract

Throughout life, neural stem cells (NSCs) in different domains of the ventricular-subventricular zone (V-SVZ) of the adult rodent brain generate several subtypes of interneurons that regulate the function of the olfactory bulb. The full extent of diversity among adult NSCs and their progeny is not known. Here, we report the generation of at least four previously unknown olfactory bulb interneuron subtypes that are produced in finely patterned progenitor domains in the anterior ventral V-SVZ of both the neonatal and adult mouse brain. Progenitors of these interneurons are responsive to sonic hedgehog and are organized into microdomains that correlate with the expression domains of the Nkx6.2 and Zic family of transcription factors. This work reveals an unexpected degree of complexity in the specification and patterning of NSCs in the postnatal mouse brain.

Year of Publication
2014
Journal
Nat Neurosci
Volume
17
Issue
2
Pages
207-14
Date Published
2014 Feb
ISSN
1546-1726
URL
DOI
10.1038/nn.3610
PubMed ID
24362763
PubMed Central ID
PMC4100623
Links
Grant list
R01 NS028478 / NS / NINDS NIH HHS / United States
207807 / European Research Council / International
86419 / Medical Research Council / United Kingdom
G0501173 / Medical Research Council / United Kingdom
HD 32116 / HD / NICHD NIH HHS / United States
Howard Hughes Medical Institute / United States
R37 HD032116 / HD / NICHD NIH HHS / United States
NS 28478 / NS / NINDS NIH HHS / United States
R37 NS028478 / NS / NINDS NIH HHS / United States
R01 HD032116 / HD / NICHD NIH HHS / United States