Scientific Publications

The complete genome sequence of a Neanderthal from the Altai Mountains.

Publication TypeJournal Article
AuthorsPrüfer, K., Racimo F., Patterson N., Jay F., Sankararaman S., Sawyer S., Heinze A., Renaud G., Sudmant PH, de Filippo C., Li H., Mallick S., Dannemann M., Fu Q., Kircher M., Kuhlwilm M., Lachmann M., Meyer M., Ongyerth M., Siebauer M., Theunert C., Tandon A., Moorjani P., Pickrell J., Mullikin JC, Vohr SH, Green RE, Hellmann I., Johnson PL, Blanche H., Cann H., Kitzman JO, Shendure J., Eichler EE, Lein ES, Bakken TE, Golovanova LV, Doronichev VB, Shunkov MV, Derevianko AP, Viola B., Slatkin M., Reich D., Kelso J., and Pääbo S.
AbstractWe present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neanderthals, Denisovans and early modern humans, possibly including gene flow into Denisovans from an unknown archaic group. Thus, interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene. In addition, the high-quality Neanderthal genome allows us to establish a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans.
Year of Publication2014
JournalNature
Volume505
Issue7481
Pages43-9
Date Published (YYYY/MM/DD)2014/01/02
ISSN Number0028-0836
DOI10.1038/nature12886
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24352235?dopt=Abstract