Scientific Publications

Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations.

Publication TypeJournal Article
AuthorsNan, H., Morikawa T., Suuriniemi M., Imamura Y., Werner L., Kuchiba A., Yamauchi M., Hunter DJ, Kraft P., Giovannucci EL, Fuchs CS, Ogino S., Freedman ML, and Chan AT
AbstractRegular aspirin use reduces the risk for colorectal cancer (CRC), possibly through inhibition of WNT/cadherin-associated protein β1 (CTNNB1 or β-catenin) signaling. The single nucleotide polymorphism (SNP) rs6983267 on chromosome 8q24 is a CRC susceptibility locus that affects binding activity of transcription factor 7 like-2 (TCF7L2) to CTNNB1, thereby altering expression of target oncogenes, including MYC.
Year of Publication2013
JournalJournal of the National Cancer Institute
Volume105
Issue24
Pages1852-61
Date Published (YYYY/MM/DD)2013/12/18
ISSN Number0027-8874
DOI10.1093/jnci/djt331
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24317174?dopt=Abstract