Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

Stroke
Authors
Keywords
Abstract

BACKGROUND AND PURPOSE: Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases.

METHODS: Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P

RESULTS: Common variants associated with CAD at P

CONCLUSIONS: Our results demonstrate substantial overlap in the genetic risk of IS and particularly the LAS subtype with CAD.

Year of Publication
2014
Journal
Stroke
Volume
45
Issue
1
Pages
24-36
Date Published
2014 Jan
ISSN
1524-4628
URL
DOI
10.1161/STROKEAHA.113.002707
PubMed ID
24262325
PubMed Central ID
PMC4112102
Links
Grant list
N01HC55020 / HL / NHLBI NIH HHS / United States
090532/Z/09/Z / Wellcome Trust / United Kingdom
HHSN268201100012C / HL / NHLBI NIH HHS / United States
P01 HL087018 / HL / NHLBI NIH HHS / United States
UL1RR025005 / RR / NCRR NIH HHS / United States
N02-HL-6-4278 / HL / NHLBI NIH HHS / United States
N01-HC-25195 / HC / NHLBI NIH HHS / United States
UL1 RR033176 / RR / NCRR NIH HHS / United States
U01 HG 004446 / HG / NHGRI NIH HHS / United States
HHSN268201100009I / HL / NHLBI NIH HHS / United States
084723/Z/08/Z / Wellcome Trust / United Kingdom
Z01 AG000015 / AG / NIA NIH HHS / United States
R01 HL089650 / HL / NHLBI NIH HHS / United States
UL1RR033176 / RR / NCRR NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States
R01 NS45012 / NS / NINDS NIH HHS / United States
R01 NS045012 / NS / NINDS NIH HHS / United States
R01 NS017950 / NS / NINDS NIH HHS / United States
R01 NS042733 / NS / NINDS NIH HHS / United States
N01AG12100 / AG / NIA NIH HHS / United States
U01 HG004446 / HG / NHGRI NIH HHS / United States
N01HC55018 / HL / NHLBI NIH HHS / United States
HHSN268 201100011C / PHS HHS / United States
R01 HL087647 / HL / NHLBI NIH HHS / United States
095626 / Wellcome Trust / United Kingdom
R01 HL103931 / HL / NHLBI NIH HHS / United States
HHSN268201100010C / HL / NHLBI NIH HHS / United States
UL1 RR025005 / RR / NCRR NIH HHS / United States
R01 AG015928 / AG / NIA NIH HHS / United States
SP/04/002 / British Heart Foundation / United Kingdom
HHSN268201100008C / HL / NHLBI NIH HHS / United States
U01 HL080295 / HL / NHLBI NIH HHS / United States
R01 HL087676 / HL / NHLBI NIH HHS / United States
HHSN268201100005G / HL / NHLBI NIH HHS / United States
R01H L59367 / PHS HHS / United States
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N01-HC-55022 / HC / NHLBI NIH HHS / United States
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HHSN268201100005C / PHS HHS / United States
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HHSN268201100007C / HL / NHLBI NIH HHS / United States
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Z01 AG-000015-50 / AG / NIA NIH HHS / United States
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HHSN268201100009C / PHS HHS / United States
G0700931 / Medical Research Council / United Kingdom
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HHSN268201100011C / HL / NHLBI NIH HHS / United States
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AG-20098 / AG / NIA NIH HHS / United States
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P01 HL076491 / HL / NHLBI NIH HHS / United States
HL087652 / HL / NHLBI NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States
N01HC55222 / HL / NHLBI NIH HHS / United States
N01-HC-55021 / HC / NHLBI NIH HHS / United States
MC_U137686857 / Medical Research Council / United Kingdom
N01-HC-85086 / HC / NHLBI NIH HHS / United States
N01HC55015 / HL / NHLBI NIH HHS / United States
R01 DK080732 / DK / NIDDK NIH HHS / United States
R01-HL087641 / HL / NHLBI NIH HHS / United States
R01 HL093029 / HL / NHLBI NIH HHS / United States
NS17950 / NS / NINDS NIH HHS / United States
R01DK080732 / DK / NIDDK NIH HHS / United States
HHSN268201100010C / PHS HHS / United States
N01HC85086 / HL / NHLBI NIH HHS / United States
R01 HL105756 / HL / NHLBI NIH HHS / United States
U01HG004402 / HG / NHGRI NIH HHS / United States
RE/08/004 / British Heart Foundation / United Kingdom
AG-027058 / AG / NIA NIH HHS / United States
N01-HC-85082 / HC / NHLBI NIH HHS / United States
R01 NS-42733 / NS / NINDS NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
HHSN268200782096C / HG / NHGRI NIH HHS / United States
HHSN268201100006C / HL / NHLBI NIH HHS / United States
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HHSN268201100012C / PHS HHS / United States
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R01HL087641 / HL / NHLBI NIH HHS / United States
U01 NS069208 / NS / NINDS NIH HHS / United States
R01 NS039987 / NS / NINDS NIH HHS / United States
P01 HL098055 / HL / NHLBI NIH HHS / United States
P01HL087018 / HL / NHLBI NIH HHS / United States
N01-HC-55015 / HC / NHLBI NIH HHS / United States
HHSN268201100005I / HL / NHLBI NIH HHS / United States
R01-HL093029 / HL / NHLBI NIH HHS / United States
HL93029 / HL / NHLBI NIH HHS / United States
N01-HC-85083 / HC / NHLBI NIH HHS / United States
090532 / Wellcome Trust / United Kingdom
N01-HC-75150 / HC / NHLBI NIH HHS / United States
1R01HL103931-01 / HL / NHLBI NIH HHS / United States
N01-HC-55020 / HC / NHLBI NIH HHS / United States
N01-HC-85080 / HC / NHLBI NIH HHS / United States
WT084724MA / Wellcome Trust / United Kingdom
Z01 AG-000954-06 / AG / NIA NIH HHS / United States
N01HC55016 / HL / NHLBI NIH HHS / United States
R01 HL080295 / HL / NHLBI NIH HHS / United States
MOP-82810 / Canadian Institutes of Health Research / Canada
ZIA HL006002-06 / Intramural NIH HHS / United States
085475/B/08/Z / Wellcome Trust / United Kingdom
G0601966 / Medical Research Council / United Kingdom
HHSN268201100007C / PHS HHS / United States
HHSN26820110 0008C / PHS HHS / United States
R01HL089650-02 / HL / NHLBI NIH HHS / United States
MOP172605 / Canadian Institutes of Health Research / Canada
N01 HC085084 / HC / NHLBI NIH HHS / United States
R01 AG020098 / AG / NIA NIH HHS / United States
N01HC55019 / HL / NHLBI NIH HHS / United States
N01HC85082 / HL / NHLBI NIH HHS / United States
U01 HG004436 / HG / NHGRI NIH HHS / United States
N01HC75150 / HL / NHLBI NIH HHS / United States
HHSN268201100009C / HL / NHLBI NIH HHS / United States
N01HC85083 / HL / NHLBI NIH HHS / United States
HHSN268201100005C / HL / NHLBI NIH HHS / United States
N01HC25195 / HL / NHLBI NIH HHS / United States
Z99 HL999999 / Intramural NIH HHS / United States
DK063491 / DK / NIDDK NIH HHS / United States
075491/Z/04 / Wellcome Trust / United Kingdom
HHSN268201100007I / HL / NHLBI NIH HHS / United States
N01-HC-85079 / HC / NHLBI NIH HHS / United States
HHSN268201200036C / PHS HHS / United States
U01 NS069208-01 / NS / NINDS NIH HHS / United States
HHSN268200782096C / PHS HHS / United States
HL080295 / HL / NHLBI NIH HHS / United States
N01-HC-85239 / HC / NHLBI NIH HHS / United States
MOP77682 / Canadian Institutes of Health Research / Canada
HL087647 / HL / NHLBI NIH HHS / United States
AG-023629 / AG / NIA NIH HHS / United States
HHSN268201100006C / PHS HHS / United States
HL-093029 / HL / NHLBI NIH HHS / United States
N01-HC-55018 / HC / NHLBI NIH HHS / United States
N01HC55021 / HL / NHLBI NIH HHS / United States
R01 AG023629 / AG / NIA NIH HHS / United States
R01 HL087641 / HL / NHLBI NIH HHS / United States
R01 HL073410 / HL / NHLBI NIH HHS / United States
R01 AG027058 / AG / NIA NIH HHS / United States
N01 HC045133 / HC / NHLBI NIH HHS / United States
N01HC85080 / HL / NHLBI NIH HHS / United States
N01 HC035129 / HC / NHLBI NIH HHS / United States
R56 AG023629 / AG / NIA NIH HHS / United States
U54 RR020278 / RR / NCRR NIH HHS / United States
085475/Z/08/Z / Wellcome Trust / United Kingdom
Z01 AG000954 / AG / NIA NIH HHS / United States
R01 NS-39987 / NS / NINDS NIH HHS / United States
N01HC85081 / HL / NHLBI NIH HHS / United States
R01HL086694 / HL / NHLBI NIH HHS / United States
P01HL076491-06 / HL / NHLBI NIH HHS / United States