The use of small molecules in somatic-cell reprogramming.
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Abstract | Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription factors share a common history starting with the early AZA and MyoD experiments in fibroblast cells. Recent work shows that a combination of small molecules can replace all of the reprogramming factors and many previous studies have demonstrated their use in enhancing efficiencies or replacing individual factors. Here we provide a brief introduction to reprogramming followed by a detailed review of the major classes of small molecules that have been used to date and what future opportunities can be expected from these. |
Year of Publication | 2014
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Journal | Trends Cell Biol
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Volume | 24
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Issue | 3
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Pages | 179-87
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Date Published | 2014 Mar
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ISSN | 1879-3088
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URL | |
DOI | 10.1016/j.tcb.2013.09.011
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PubMed ID | 24183602
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PubMed Central ID | PMC3943685
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Grant list | P01 GM099117 / GM / NIGMS NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States
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