The use of small molecules in somatic-cell reprogramming.

Trends Cell Biol
Authors
Keywords
Abstract

Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription factors share a common history starting with the early AZA and MyoD experiments in fibroblast cells. Recent work shows that a combination of small molecules can replace all of the reprogramming factors and many previous studies have demonstrated their use in enhancing efficiencies or replacing individual factors. Here we provide a brief introduction to reprogramming followed by a detailed review of the major classes of small molecules that have been used to date and what future opportunities can be expected from these.

Year of Publication
2014
Journal
Trends Cell Biol
Volume
24
Issue
3
Pages
179-87
Date Published
2014 Mar
ISSN
1879-3088
URL
DOI
10.1016/j.tcb.2013.09.011
PubMed ID
24183602
PubMed Central ID
PMC3943685
Links
Grant list
P01 GM099117 / GM / NIGMS NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States