Scientific Publications

Criteria for the use of omics-based predictors in clinical trials.

Publication TypeJournal Article
AuthorsMcShane, LM, Cavenagh MM, Lively TG, Eberhard DA, Bigbee WL, Williams PM, Mesirov J. P., Polley MY, Kim KY, Tricoli JV, Taylor JM, Shuman DJ, Simon RM, Doroshow JH, and Conley BA
AbstractThe US National Cancer Institute (NCI), in collaboration with scientists representing multiple areas of expertise relevant to 'omics'-based test development, has developed a checklist of criteria that can be used to determine the readiness of omics-based tests for guiding patient care in clinical trials. The checklist criteria cover issues relating to specimens, assays, mathematical modelling, clinical trial design, and ethical, legal and regulatory aspects. Funding bodies and journals are encouraged to consider the checklist, which they may find useful for assessing study quality and evidence strength. The checklist will be used to evaluate proposals for NCI-sponsored clinical trials in which omics tests will be used to guide therapy.
Year of Publication2013
JournalNature
Volume502
Issue7471
Pages317-20
Date Published (YYYY/MM/DD)2013/10/17
ISSN Number0028-0836
DOI10.1038/nature12564
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24132288?dopt=Abstract