Scientific Publications

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

Publication TypeJournal Article
AuthorsVaishnavi, A., Capelletti M., Le AT, Kako S., Butaney M., Ercan D., Mahale S., Davies KD, Aisner DL, Pilling AB, Berge EM, Kim J., Sasaki H., Park SI, Kryukov G., Garraway LA, Hammerman PS, Haas J., Andrews SW, Lipson D., Stephens PJ, Miller VA, Varella-Garcia M., Jänne PA, and Doebele RC
AbstractWe identified new gene fusions in patients with lung cancer harboring the kinase domain of the NTRK1 gene that encodes the high-affinity nerve growth factor receptor (TRKA protein). Both the MPRIP-NTRK1 and CD74-NTRK1 fusions lead to constitutive TRKA kinase activity and are oncogenic. Treatment of cells expressing NTRK1 fusions with inhibitors of TRKA kinase activity inhibited autophosphorylation of TRKA and cell growth. Tumor samples from 3 of 91 patients with lung cancer (3.3%) without known oncogenic alterations assayed by next-generation sequencing or fluorescence in situ hybridization demonstrated evidence of NTRK1 gene fusions.
Year of Publication2013
JournalNature medicine
Date Published (YYYY/MM/DD)2013/10/27
ISSN Number1078-8956
DOI10.1038/nm.3352
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24162815?dopt=Abstract