Scientific Publications

Connecting Genomic Alterations to Cancer Biology with Proteomics: The NCI Clinical Proteomic Tumor Analysis Consortium.

Publication TypeJournal Article
AuthorsEllis, MJ, Gillette M., Carr SA, Paulovich AG, Smith RD, Rodland KK, Townsend RR, Kinsinger C., Mesri M., Rodriguez H., Liebler DC, and Clinical Proteomic Tumor Analysis Consortium(CPTAC)
AbstractSummary: The National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium is applying the latest generation of proteomic technologies to genomically annotated tumors from The Cancer Genome Atlas (TCGA) program, a joint initiative of the NCI and the National Human Genome Research Institute. By providing a fully integrated accounting of DNA, RNA, and protein abnormalities in individual tumors, these datasets will illuminate the complex relationship between genomic abnormalities and cancer phenotypes, thus producing biologic insights as well as a wave of novel candidate biomarkers and therapeutic targets amenable to verification using targeted mass spectrometry methods. Cancer Discov; 3(10); 1108-12. ©2013 AACR.
Year of Publication2013
JournalCancer discovery
Volume3
Issue10
Pages1108-12
Date Published (YYYY/MM/DD)2013/10/01
ISSN Number2159-8274
DOI10.1158/2159-8290.CD-13-0219
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24124232?dopt=Abstract