Scientific Publications

Colorectal Cancers from Distinct Ancestral Populations Show Variations in BRAF Mutation Frequency.

Publication TypeJournal Article
AuthorsHanna, MC, Go C., Roden C., Jones RT, Pochanard P., Javed AY, Javed A., Mondal C., Palescandolo E., Van Hummelen P., Hatton C., Bass AJ, Chun SM, Na DC, Kim TI, Jang SJ, Osarogiagbon RU, Hahn WC, Meyerson M., Garraway LA, and Macconaill LE
AbstractIt has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 33 known cancer genes in colorectal cancer DNA from 83 Asian, 149 Black and 195 White patients. We found that Asian patients had fewer canonical oncogenic mutations in the genes tested (60% vs Black 79% (P = 0.011) and White 77% (P = 0.015)), and that BRAF mutations occurred at a higher frequency in White patients (17% vs Asian 4% (P = 0.004) and Black 7% (P = 0.014)). These results suggest that the use of genomic approaches to elucidate the different ancestral determinants harbored by patient populations may help to more precisely and effectively treat colorectal cancer.
Year of Publication2013
JournalPloS one
Volume8
Issue9
Pagese74950
Date Published (YYYY/MM/DD)2013/09/16
DOI10.1371/journal.pone.0074950
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/24066160?dopt=Abstract