Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

Nat Genet
Authors
Keywords
Abstract

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

Year of Publication
2013
Journal
Nat Genet
Volume
45
Issue
10
Pages
1150-9
Date Published
2013 Oct
ISSN
1546-1718
URL
DOI
10.1038/ng.2742
PubMed ID
23974872
PubMed Central ID
PMC3827979
Links
Grant list
R01 MH095034 / MH / NIMH NIH HHS / United States
095552 / Wellcome Trust / United Kingdom
R01 MH077139 / MH / NIMH NIH HHS / United States
G0601635 / Medical Research Council / United Kingdom
G1100583 / Medical Research Council / United Kingdom
K01 MH094406 / MH / NIMH NIH HHS / United States
090532 / Wellcome Trust / United Kingdom
G0701420 / Medical Research Council / United Kingdom
085475/B/08/Z / Wellcome Trust / United Kingdom
G0600429 / Medical Research Council / United Kingdom
G0901310 / Medical Research Council / United Kingdom
R01 MH083094 / MH / NIMH NIH HHS / United States
U01 MH094421 / MH / NIMH NIH HHS / United States
PDA/02/06/016 / Department of Health / United Kingdom
G0800509 / Medical Research Council / United Kingdom
G1000718 / Medical Research Council / United Kingdom
085475/Z/08/Z / Wellcome Trust / United Kingdom