Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
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Abstract | Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder. |
Year of Publication | 2013
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Journal | Nat Genet
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Volume | 45
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Issue | 10
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Pages | 1150-9
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Date Published | 2013 Oct
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ISSN | 1546-1718
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URL | |
DOI | 10.1038/ng.2742
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PubMed ID | 23974872
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PubMed Central ID | PMC3827979
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Grant list | R01 MH095034 / MH / NIMH NIH HHS / United States
095552 / Wellcome Trust / United Kingdom
R01 MH077139 / MH / NIMH NIH HHS / United States
G0601635 / Medical Research Council / United Kingdom
G1100583 / Medical Research Council / United Kingdom
K01 MH094406 / MH / NIMH NIH HHS / United States
090532 / Wellcome Trust / United Kingdom
G0701420 / Medical Research Council / United Kingdom
085475/B/08/Z / Wellcome Trust / United Kingdom
G0600429 / Medical Research Council / United Kingdom
G0901310 / Medical Research Council / United Kingdom
R01 MH083094 / MH / NIMH NIH HHS / United States
U01 MH094421 / MH / NIMH NIH HHS / United States
PDA/02/06/016 / Department of Health / United Kingdom
G0800509 / Medical Research Council / United Kingdom
G1000718 / Medical Research Council / United Kingdom
085475/Z/08/Z / Wellcome Trust / United Kingdom
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