Scientific Publications

Targeted therapy for squamous cell lung cancer.

Publication TypeJournal Article
AuthorsLiao, RG, Watanabe H., Meyerson M., and Hammerman PS
AbstractLung squamous cell carcinoma (SqCC) is the second most common subtype of non-small-cell lung cancer and leads to 40,000-50,000 deaths per year in the USA. Management of non-small-cell lung cancer has dramatically changed over the past decade with the introduction of targeted therapeutic agents for genotypically selected individuals with lung adenocarcinoma. These agents lead to improved outcomes, and it has now become the standard of care to perform routine molecular genotyping of lung adenocarcinomas. By contrast, progress in lung SqCC has been modest, and there has yet to be a successful demonstration of targeted therapy in this disease. Here, we review exciting work from ongoing genomic characterization and biomarker validation efforts that have nominated several likely therapeutic targets in lung SqCCs. These studies suggest that targeted therapies are likely to be successful in the treatment of lung SqCCs and should be further explored in both preclinical models and in clinical trials.
Year of Publication2012
JournalLung cancer management
Volume1
Issue4
Pages293-300
Date Published (YYYY/MM/DD)2012/12/01
ISSN Number1758-1966
DOI10.2217/lmt.12.40
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23956794?dopt=Abstract