Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
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Abstract | PURPOSE: Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. PATIENTS AND METHODS: We determined subgroup affiliation, TP53 mutation status, and clinical outcome in a discovery cohort of 397 medulloblastomas. We subsequently validated our results on an independent cohort of 156 medulloblastomas. RESULTS: TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medulloblastomas and are virtually absent in subgroups 3 and 4 tumors (P CONCLUSION: Subgroup-specific analysis reconciles prior conflicting publications and confirms that TP53 mutations are enriched among SHH medulloblastomas, in which they portend poor outcome and account for a large proportion of treatment failures in these patients. |
Year of Publication | 2013
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Journal | J Clin Oncol
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Volume | 31
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Issue | 23
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Pages | 2927-35
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Date Published | 2013 Aug 10
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ISSN | 1527-7755
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URL | |
DOI | 10.1200/JCO.2012.48.5052
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PubMed ID | 23835706
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PubMed Central ID | PMC4878050
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Grant list | P30 HD018655 / HD / NICHD NIH HHS / United States
R01 CA109467 / CA / NCI NIH HHS / United States
Cancer Research UK / United Kingdom
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