Scientific Publications

Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.

Publication TypeJournal Article
AuthorsGerard, B., Lee MD 4th, Dandapani S., Duvall JR, Fitzgerald ME, Kesavan S., Lowe JT, Marié JC, Pandya BA, Suh BC, O'Shea MW, Dombrowski M., Hamann D., Lemercier B., Murillo T., Akella LB, Foley MA, and Marcaurelle LA
AbstractA diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochemically diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and methyl ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) analysis.
Year of Publication2013
JournalThe Journal of organic chemistry
Volume78
Issue11
Pages5160-71
Date Published (YYYY/MM/DD)2013/06/07
ISSN Number0022-3263
DOI10.1021/jo4000916
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23692141?dopt=Abstract