Scientific Publications

Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal.

Publication TypeJournal Article
AuthorsDaniels, R., Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D., Mboup S., Sabeti PC, Ndiaye D., Wirth DF, Hartl DL, and Volkman SK
AbstractUsing parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign.
Year of Publication2013
JournalPloS one
Volume8
Issue4
Pagese60780
Date Published (YYYY/MM/DD)2013/01/01
DOI10.1371/journal.pone.0060780
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23593309?dopt=Abstract