Recent Broad Publications
- A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration.
Read More / View Supplemental Materials - Synthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C-Glycosides.
Read More / View Supplemental Materials - RhoGTPases - NODes for effector-triggered immunity in animals.
Read More / View Supplemental Materials - Comparative analysis of RNA sequencing methods for degraded or low-input samples.
Read More / View Supplemental Materials - Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.
Read More / View Supplemental Materials
| Publication Type | Journal Article |
| Authors | Moorjani, P., Patterson N., Loh PR, Lipson M., Kisfali P., Melegh BI, Bonin M., Kádaši L., Rieß O., Berger B., Reich D., and Melegh B. |
| Abstract | The Roma people, living throughout Europe and West Asia, are a diverse population linked by the Romani language and culture. Previous linguistic and genetic studies have suggested that the Roma migrated into Europe from South Asia about 1,000-1,500 years ago. Genetic inferences about Roma history have mostly focused on the Y chromosome and mitochondrial DNA. To explore what additional information can be learned from genome-wide data, we analyzed data from six Roma groups that we genotyped at hundreds of thousands of single nucleotide polymorphisms (SNPs). We estimate that the Roma harbor about 80% West Eurasian ancestry-derived from a combination of European and South Asian sources-and that the date of admixture of South Asian and European ancestry was about 850 years before present. We provide evidence for Eastern Europe being a major source of European ancestry, and North-west India being a major source of the South Asian ancestry in the Roma. By computing allele sharing as a measure of linkage disequilibrium, we estimate that the migration of Roma out of the Indian subcontinent was accompanied by a severe founder event, which appears to have been followed by a major demographic expansion after the arrival in Europe. |
| Year of Publication | 2013 |
| Journal | PloS one |
| Volume | 8 |
| Issue | 3 |
| Pages | e58633 |
| Date Published (YYYY/MM/DD) | 2013/01/01 |
| DOI | 10.1371/journal.pone.0058633 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/23516520?dopt=Abstract |
Share This
- Tweet
