An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation.

Cell Stem Cell
Authors
Abstract

Although SOX2 has been identified as a squamous cell carcinoma oncogene, mechanisms of SOX2-induce oncogenesis have remained elusive. In this issue of Cell Stem Cell, Li et al. (2013) show that SOX2 synergizes with inflammation-induced STAT3 activation to transform basal progenitors and initiate squamous cell carcinoma.

Year of Publication
2013
Journal
Cell Stem Cell
Volume
12
Issue
3
Pages
266-8
Date Published
2013 Mar 07
ISSN
1875-9777
URL
DOI
10.1016/j.stem.2013.02.004
PubMed ID
23472866
Links