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Selective access to trisubstituted macrocyclic e- and z-alkenes from the ring-closing metathesis of vinylsiloxanes.
| Publication Type | Journal Article |
| Authors | Wang, Y., Jimenez M., Sheehan P., Zhong C., Hung AW, Tam CP, and Young DW |
| Abstract | Macrocyclic (E)-alkenylsiloxanes, obtained from E-selective ring-closing metathesis reactions, can be converted to the corresponding (Z)-alkenyl bromides and (E)-alkenyl iodides allowing access to both E- and Z-trisubstituted macrocyclic alkenes. The reaction conditions and substrate scope of these stereoselective transformations are explored. |
| Year of Publication | 2013 |
| Journal | Organic letters |
| Volume | 15 |
| Issue | 6 |
| Pages | 1218-21 |
| Date Published (YYYY/MM/DD) | 2013/03/15 |
| ISSN Number | 1523-7060 |
| DOI | 10.1021/ol400134d |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/23448432?dopt=Abstract |
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