Scientific Publications

Selective access to trisubstituted macrocyclic e- and z-alkenes from the ring-closing metathesis of vinylsiloxanes.

Publication TypeJournal Article
AuthorsWang, Y., Jimenez M., Sheehan P., Zhong C., Hung AW, Tam CP, and Young DW
AbstractMacrocyclic (E)-alkenylsiloxanes, obtained from E-selective ring-closing metathesis reactions, can be converted to the corresponding (Z)-alkenyl bromides and (E)-alkenyl iodides allowing access to both E- and Z-trisubstituted macrocyclic alkenes. The reaction conditions and substrate scope of these stereoselective transformations are explored.
Year of Publication2013
JournalOrganic letters
Volume15
Issue6
Pages1218-21
Date Published (YYYY/MM/DD)2013/03/15
ISSN Number1523-7060
DOI10.1021/ol400134d
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23448432?dopt=Abstract