Effector-triggered versus pattern-triggered immunity: how animals sense pathogens.

Nat Rev Immunol
Authors
Keywords
Abstract

A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.

Year of Publication
2013
Journal
Nat Rev Immunol
Volume
13
Issue
3
Pages
199-206
Date Published
2013 03
ISSN
1474-1741
URL
DOI
10.1038/nri3398
PubMed ID
23411798
PubMed Central ID
PMC4121468
Links
Grant list
R01 AI079198 / AI / NIAID NIH HHS / United States
R01 GM102482 / GM / NIGMS NIH HHS / United States
U54 AI057159 / AI / NIAID NIH HHS / United States