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Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
| Publication Type | Journal Article |
| Authors | Germain, AR, Carmody LC, Nag PP, Morgan B., VerPlank L., Fernandez C., Donckele E., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B. |
| Abstract | A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations. |
| Year of Publication | 2013 |
| Journal | Bioorganic & medicinal chemistry letters |
| Volume | 23 |
| Issue | 6 |
| Pages | 1834-8 |
| Date Published (YYYY/MM/DD) | 2013/03/15 |
| ISSN Number | 0960-894X |
| DOI | 10.1016/j.bmcl.2013.01.025 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/23403082?dopt=Abstract |
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