Scientific Publications

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Publication TypeJournal Article
AuthorsGermain, AR, Carmody LC, Nag PP, Morgan B., VerPlank L., Fernandez C., Donckele E., Feng Y., Perez JR, Dandapani S., Palmer M., Lander E. S., Gupta PB, Schreiber SL, and Munoz B.
AbstractA high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure-activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations.
Year of Publication2013
JournalBioorganic & medicinal chemistry letters
Volume23
Issue6
Pages1834-8
Date Published (YYYY/MM/DD)2013/03/15
ISSN Number0960-894X
DOI10.1016/j.bmcl.2013.01.025
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23403082?dopt=Abstract