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Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.
| Publication Type | Journal Article |
| Authors | Chmielecki, J., Crago AM, Rosenberg M., O'Connor R., Walker SR, Ambrogio L., Auclair D., McKenna A., Heinrich MC, Frank DA, and Meyerson M. |
| Abstract | Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs. |
| Year of Publication | 2013 |
| Journal | Nature genetics |
| Volume | 45 |
| Issue | 2 |
| Pages | 131-2 |
| Date Published (YYYY/MM/DD) | 2013/02/01 |
| ISSN Number | 1061-4036 |
| DOI | 10.1038/ng.2522 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/23313954?dopt=Abstract |
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