Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

Nat Genet
Authors
Keywords
Abstract

Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.

Year of Publication
2013
Journal
Nat Genet
Volume
45
Issue
2
Pages
131-2
Date Published
2013 Feb
ISSN
1546-1718
URL
DOI
10.1038/ng.2522
PubMed ID
23313954
PubMed Central ID
PMC3984043
Links
Grant list
P01 CA047179 / CA / NCI NIH HHS / United States
P50 CA140146 / CA / NCI NIH HHS / United States
P01CA47179 / CA / NCI NIH HHS / United States