Scientific Publications

Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

Publication TypeJournal Article
AuthorsChmielecki, J., Crago AM, Rosenberg M., O'Connor R., Walker SR, Ambrogio L., Auclair D., McKenna A., Heinrich MC, Frank DA, and Meyerson M.
AbstractSolitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
Year of Publication2013
JournalNature genetics
Volume45
Issue2
Pages131-2
Date Published (YYYY/MM/DD)2013/02/01
ISSN Number1061-4036
DOI10.1038/ng.2522
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/23313954?dopt=Abstract