Scientific Publications

Transcriptional regulatory circuits: predicting numbers from alphabets.

Publication TypeJournal Article
AuthorsKim, HD, Shay T., O'Shea EK, and Regev A.
AbstractTranscriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits.
Year of Publication2009
JournalScience (New York, N.Y.)
Volume325
Issue5939
Pages429-32
Date Published (YYYY/MM/DD)2009/07/24
ISSN Number0036-8075
DOI10.1126/science.1171347
PubMedhttp://www.ncbi.nlm.nih.gov/pubmed/19628860?dopt=Abstract