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Transcriptional regulatory circuits: predicting numbers from alphabets.
| Publication Type | Journal Article |
| Authors | Kim, HD, Shay T., O'Shea EK, and Regev A. |
| Abstract | Transcriptional regulatory circuits govern how cis and trans factors transform signals into messenger RNA (mRNA) expression levels. With advances in quantitative and high-throughput technologies that allow measurement of gene expression state in different conditions, data that can be used to build and test models of transcriptional regulation is being generated at a rapid pace. Here, we review experimental and computational methods used to derive detailed quantitative circuit models on a small scale and cruder, genome-wide models on a large scale. We discuss the potential of combining small- and large-scale approaches to understand the working and wiring of transcriptional regulatory circuits. |
| Year of Publication | 2009 |
| Journal | Science (New York, N.Y.) |
| Volume | 325 |
| Issue | 5939 |
| Pages | 429-32 |
| Date Published (YYYY/MM/DD) | 2009/07/24 |
| ISSN Number | 0036-8075 |
| DOI | 10.1126/science.1171347 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/19628860?dopt=Abstract |
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