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Hits, leads and drugs against malaria through diversity-oriented synthesis.
| Publication Type | Journal Article |
| Authors | Dandapani, S., Comer E., Duvall JR, and Munoz B. |
| Abstract | Malaria is a devastating infectious disease and approximately half the world's population is at risk. Since vaccination is not yet available, small-molecule-based medicines are currently the best option for the treatment of patients suffering from malaria and combating the spread of infection. Development of resistance against existing drugs has created a need for new types of small molecules to be screened against Plasmodium falciparum, the etiological agent of malaria. The advent of diversity-oriented synthesis has enabled access to novel chemical structures. Evaluation of diversity-oriented synthesis compounds in phenotypic assays for growth inhibition of P. falciparum has resulted in novel hits, leads and even investigational drugs against malaria. |
| Year of Publication | 2012 |
| Journal | Future medicinal chemistry |
| Volume | 4 |
| Issue | 18 |
| Pages | 2279-94 |
| Date Published (YYYY/MM/DD) | 2012/12/01 |
| ISSN Number | 1756-8919 |
| DOI | 10.4155/fmc.12.178 |
| PubMed | http://www.ncbi.nlm.nih.gov/pubmed/23234551?dopt=Abstract |
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