Scientific Publications

Hits, leads and drugs against malaria through diversity-oriented synthesis.

Publication TypeJournal Article
AuthorsDandapani, S., Comer E., Duvall JR, and Munoz B.
AbstractMalaria is a devastating infectious disease and approximately half the world's population is at risk. Since vaccination is not yet available, small-molecule-based medicines are currently the best option for the treatment of patients suffering from malaria and combating the spread of infection. Development of resistance against existing drugs has created a need for new types of small molecules to be screened against Plasmodium falciparum, the etiological agent of malaria. The advent of diversity-oriented synthesis has enabled access to novel chemical structures. Evaluation of diversity-oriented synthesis compounds in phenotypic assays for growth inhibition of P. falciparum has resulted in novel hits, leads and even investigational drugs against malaria.
Year of Publication2012
JournalFuture medicinal chemistry
Date Published (YYYY/MM/DD)2012/12/01
ISSN Number1756-8919