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Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.
|Publication Type||Journal Article|
|Authors||Gifford, CA, and Meissner A.|
|Abstract||Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to provide mechanistic insights that will eventually lead to a more rational design and improved understanding of nuclear reprogramming.|
|Year of Publication||2012|
|Journal||Current opinion in genetics & development|
|Date Published (YYYY/MM/DD)||2012/08/23|